Data may be available for researchers who meet the criteria for access to confidential data after evaluation from affiliated IRB and VA Research and Development Committees. The work is made available under the Creative Commons CC0 public domain dedication.ĭata Availability: Data cannot be shared publicly because it involves sensitive human subject information. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Received: Accepted: ApPublished: May 5, 2022 PLoS ONE 17(5):Įditor: Chiara Lazzeri, Azienda Ospedaliero Universitaria Careggi, ITALY Although the study design cannot determine causality, the study should assure patients as it finds no association between mortality and chronic use of these medications compared with sporadic NSAID use among those infected with COVID-19.Ĭitation: Campbell HM, Murata AE, Conner TA, Fotieo G (2022) Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) or acetaminophen and relationship with mortality among United States Veterans after testing positive for COVID-19. Then, we used multivariate logistic regression incorporating inverse propensity score weighting to assess mortality.
Using established and possible risk factors for severe COVID-19, we used propensity scores analysis to adjust for differences in baseline characteristics between treatment groups. We used the VA national datasets in this retrospective cohort study to differentiate between sporadic and chronic medication use: sporadic users filled an NSAID within the last year, but not recently or regularly. Our objective was to study treatment effects of chronic use of individual NSAID medications and acetaminophen on all-cause mortality among patients who tested positive for COVID-19 while accounting for adherence. Although these medications have different mechanisms of action, they have similar indications and treatment duration has been positively correlated with cardiovascular risk although the degree of risk varies by medication. Non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are among the most-frequently used medications.
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